Disruption of Aneuploidy and Senescence induced by Aurora inhibition promotes intrinsic Apoptosis in double hit or double expresser Diffuse Large B-cell Lymphomas

Double Hit (DH) or Double Expresser (DE) diffuse large B-cell lymphoma (DLBCL) are aggressive Non-Hodgkin’s Lymphomas (NHLs) with translocations and/or over-expression of MYC and BCL-2, that are difficult to treat. Aurora kinase (AK) inhibition with alisertib in DH/DE-DLBCL induces cell death in ~30...

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Publicat a:Mol Cancer Ther
Autors principals: Islam, Shariful, Qi, Wenqing, Morales, Carla, Cooke, Laurence, Spier, Catherine, Weterings, Eric, Mahadevan, Daruka
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6574129/
https://ncbi.nlm.nih.gov/pubmed/28615297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0089
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