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Protein sequence editing of SKN-1A/Nrf1 by peptide:N-glycanase controls proteasome gene expression.
The proteasome mediates selective protein degradation and is dynamically regulated in response to proteotoxic challenges. SKN-1A/Nrf1, an ER-associated transcription factor that undegoes N-linked glycosylation, serves as a sensor of proteasome dysfunction and triggers compensatory upregulation of pr...
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| Publicado no: | Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6574124/ https://ncbi.nlm.nih.gov/pubmed/31002798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.03.035 |
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