CD22 blockade restores homeostatic microglial phagocytosis in aging brains

Microglia maintain homeostasis in the central nervous system (CNS) through phagocytic clearance of protein aggregates and cellular debris. This function deteriorates during aging and neurodegenerative disease, concomitant with cognitive decline. However, the mechanisms of impaired microglial homeost...

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Publicado no:Nature
Main Authors: Pluvinage, John V., Haney, Michael S., Smith, Benjamin A. H., Sun, Jerry, Iram, Tal, Bonanno, Liana, Li, Lulin, Lee, Davis P., Morgens, David W., Yang, Andrew C., Shuken, Steven R., Gate, David, Scott, Madeleine, Khatri, Purvesh, Luo, Jian, Bertozzi, Carolyn R., Bassik, Michael C., Wyss-Coray, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6574119/
https://ncbi.nlm.nih.gov/pubmed/30944478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1088-4
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