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An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus
Mice lacking the serine protease tissue plasminogen activator (tPA) are resistant to excitotoxin-mediated hippocampal neuronal degeneration. We have used genetic and cellular analyses to study the role of tPA in neuronal cell death. Mice deficient for the zymogen plasminogen, a known substrate for t...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6573220/ https://ncbi.nlm.nih.gov/pubmed/8987777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-02-00543.1997 |
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