The Tissue Plasminogen Activator (Tpa/Plasmin) Extracellular Proteolytic System Regulates Seizure-Induced Hippocampal Mossy Fiber Outgrowth through a Proteoglycan Substrate

Short seizure episodes are associated with remodeling of neuronal connections. One region where such reorganization occurs is the hippocampus, and in particular, the mossy fiber pathway. Using genetic and pharmacological approaches, we show here a critical role in vivo for tissue plasminogen activat...

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Autors principals: Wu, Yan Ping, Siao, Chia-Jen, Lu, Weiquan, Sung, Tsung-Chang, Frohman, Michael A., Milev, Peter, Bugge, Thomas H., Degen, Jay L., Levine, Joel M., Margolis, Richard U., Tsirka, Stella E.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2000
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174310/
https://ncbi.nlm.nih.gov/pubmed/10725341
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