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Knockdown of Hypoxia-Inducible Factor 1α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells
BACKGROUND: Ovarian cancer has the highest mortality rate among all female genital tumors because of its insidious onset and drug resistance. Hypoxia-inducible factor 1α (HIF-1α), one of the best-studied oncogenes, plays an important part in tumor adaptation to microenvironmental hypoxia and was fou...
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| Pubblicato in: | Med Sci Monit |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
International Scientific Literature, Inc.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6573092/ https://ncbi.nlm.nih.gov/pubmed/31175269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.915730 |
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