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Knockdown of Hypoxia-Inducible Factor 1α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells

BACKGROUND: Ovarian cancer has the highest mortality rate among all female genital tumors because of its insidious onset and drug resistance. Hypoxia-inducible factor 1α (HIF-1α), one of the best-studied oncogenes, plays an important part in tumor adaptation to microenvironmental hypoxia and was fou...

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التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Med Sci Monit
المؤلفون الرئيسيون:	Huang, Jinling, Gao, Likun, Li, Bingshu, Liu, Cheng, Hong, Shasha, Min, Jie, Hong, Li
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	International Scientific Literature, Inc. 2019
الموضوعات:	Lab/In Vitro Research
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6573092/ https://ncbi.nlm.nih.gov/pubmed/31175269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.915730
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Knockdown of Hypoxia-Inducible Factor 1α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells

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