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Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation

Transforming growth factor β is a disulfide-linked dimeric cytokine that occurs in three highly related isoforms (TGFβ1–TGFβ3) engaged in signaling functions through binding of cognate TGFβ receptors. To regulate this pathway, the cytokines are biosynthesized as inactive pro-TGFβs with an N-terminal...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: del Amo-Maestro, Laura, Marino-Puertas, Laura, Goulas, Theodoros, Gomis-Rüth, F. Xavier
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572864/
https://ncbi.nlm.nih.gov/pubmed/31209258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44943-4
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