Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor

Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either region I of MSLN (meso1 CAR, also known as a membrane-distal region) or region III of MSLN (me...

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Udgivet i:Cell Death Dis
Main Authors: Zhang, Zhiwei, Jiang, Duqing, Yang, Huan, He, Zhou, Liu, Xiangzhen, Qin, Wenxia, Li, Linfang, Wang, Chao, Li, Yang, Li, He, Xu, Hai, Jin, Huajun, Qian, Qijun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572851/
https://ncbi.nlm.nih.gov/pubmed/31209210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1711-1
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