A carregar...
Computational Simulations Identify Pyrrolidine-2,3-Dione Derivatives as Novel Inhibitors of Cdk5/p25 Complex to Attenuate Alzheimer’s Pathology
Mechanistically, neurotoxic insults provoke Ca(2+)-mediated calpain activation, which cleaves the cytoplasmic region of membrane-embedded p35 and produces its truncated form p25. Upon physical interaction, cyclin-dependent kinase 5 (Cdk5) and p25 forms hyperactivated Cdk5/p25 complex and causes seve...
Na minha lista:
| Publicado no: | J Clin Med |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6572193/ https://ncbi.nlm.nih.gov/pubmed/31137734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8050746 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|