Computational Simulations Identify Pyrrolidine-2,3-Dione Derivatives as Novel Inhibitors of Cdk5/p25 Complex to Attenuate Alzheimer’s Pathology

Mechanistically, neurotoxic insults provoke Ca(2+)-mediated calpain activation, which cleaves the cytoplasmic region of membrane-embedded p35 and produces its truncated form p25. Upon physical interaction, cyclin-dependent kinase 5 (Cdk5) and p25 forms hyperactivated Cdk5/p25 complex and causes seve...

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Vydáno v:J Clin Med
Hlavní autoři: Zeb, Amir, Kim, Donghwan, Alam, Sayed Ibrar, Son, Minky, Kumar, Raj, Rampogu, Shailima, Parameswaran, Saravanan, Shelake, Rahul Mahadev, Rana, Rabia Mukhtar, Parate, Shraddha, Kim, Jae-Yean, Lee, Keun Woo
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572193/
https://ncbi.nlm.nih.gov/pubmed/31137734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm8050746
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