Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors

Nicotine dependence is thought to arise in part because nicotine permeates into the endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an “inside-out” pathway that leads to up-regulation of nAChRs on the plasma membrane. However, the dynamics of nicotine entry into...

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Bibliographic Details
Published in:J Gen Physiol
Main Authors: Shivange, Amol V., Borden, Philip M., Muthusamy, Anand K., Nichols, Aaron L., Bera, Kallol, Bao, Huan, Bishara, Ishak, Jeon, Janice, Mulcahy, Matthew J., Cohen, Bruce, O'Riordan, Saidhbhe L., Kim, Charlene, Dougherty, Dennis A., Chapman, Edwin R., Marvin, Jonathan S., Looger, Loren L., Lester, Henry A.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2019
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571994/
https://ncbi.nlm.nih.gov/pubmed/30718376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812201
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