Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors

Nicotine dependence is thought to arise in part because nicotine permeates into the endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an “inside-out” pathway that leads to up-regulation of nAChRs on the plasma membrane. However, the dynamics of nicotine entry into...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Shivange, Amol V., Borden, Philip M., Muthusamy, Anand K., Nichols, Aaron L., Bera, Kallol, Bao, Huan, Bishara, Ishak, Jeon, Janice, Mulcahy, Matthew J., Cohen, Bruce, O'Riordan, Saidhbhe L., Kim, Charlene, Dougherty, Dennis A., Chapman, Edwin R., Marvin, Jonathan S., Looger, Loren L., Lester, Henry A.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571994/
https://ncbi.nlm.nih.gov/pubmed/30718376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812201
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