Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors

Nicotine dependence is thought to arise in part because nicotine permeates into the endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an “inside-out” pathway that leads to up-regulation of nAChRs on the plasma membrane. However, the dynamics of nicotine entry into...

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Udgivet i:J Gen Physiol
Main Authors: Shivange, Amol V., Borden, Philip M., Muthusamy, Anand K., Nichols, Aaron L., Bera, Kallol, Bao, Huan, Bishara, Ishak, Jeon, Janice, Mulcahy, Matthew J., Cohen, Bruce, O'Riordan, Saidhbhe L., Kim, Charlene, Dougherty, Dennis A., Chapman, Edwin R., Marvin, Jonathan S., Looger, Loren L., Lester, Henry A.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571994/
https://ncbi.nlm.nih.gov/pubmed/30718376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812201
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