Pathogenesis of Thalassemia Major-associated Osteoporosis: A Review with Insights from Clinical Experience

Due to increasing life expectancy in thalassemia major (TM), osteoporosis is emerging as a significant problem. Its aetiology is multifactorial, culminating in increased bone resorption and impaired remodelling. Hypogonadism and marrow expansion seem to play an important role, but iron overload, def...

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Bibliografiske detaljer
Udgivet i:J Clin Res Pediatr Endocrinol
Main Authors: Gaudio, Agostino, Morabito, Nancy, Catalano, Antonino, Rapisarda, Rosario, Xourafa, Anastasia, Lasco, Antonino
Format: Artigo
Sprog:Inglês
Udgivet: Galenos Publishing 2019
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571534/
https://ncbi.nlm.nih.gov/pubmed/29991466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4274/jcrpe.galenos.2018.2018.0074
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