Multi-omics integration analysis robustly predicts high-grade patient survival and identifies CPT1B effect on fatty acid metabolism in Bladder Cancer

PURPOSE: The perturbation of metabolic pathways in high-grade BLCA has not been investigated. We aimed to identify a metabolic signature in high-grade BLCA by integrating unbiased metabolomics, lipidomics, and transcriptomics to predict patient survival and to discover novel therapeutic targets. EXP...

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Publicado no:Clin Cancer Res
Main Authors: Vantaku, Venkatrao, Dong, Jianrong, Ambati, Chandrashekar R, Perera, Dimuthu, Donepudi, Sri Ramya, Amara, Chandra Sekhar, Putluri, Vasanta, Shiva Shankar, Ravi, Robertson, Matthew J., Piyarathna, Danthasinghe Waduge Badrajee, Villanueva, Mariana, von Rundstedt, Friedrich-Carl, Karanam, Balasubramanyam, Ballester, Leomar Y, Terris, Martha K, Bollag, Roni J, Lerner, Seth P., Andrea, Apolo B., Villanueva, Hugo, Lee, MinJae, Sikora, Andrew G., Lotan, Yair, Sreekumar, Arun, Coarfa, Cristian, Putluri, Nagireddy
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571061/
https://ncbi.nlm.nih.gov/pubmed/30846479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1515
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