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Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

Abnormal blood and lymphatic vessels create a hostile tumor microenvironment characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These abnormalities fuel tumor progression, immunosuppression, and treatment resistance. In 2001, we proposed a novel hypothesis that the judicious...

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Detalhes bibliográficos
Publicado no:Annu Rev Physiol
Main Authors: Martin, John D., Seano, Giorgio, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571025/
https://ncbi.nlm.nih.gov/pubmed/30742782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-physiol-020518-114700
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