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DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1

OBJECTIVE: To assess the effects of dystrophia myotonica protein kinase (DMPK) DNA methylation (DNAme) epivariation on muscular and respiratory profiles in patients with myotonic dystrophy type 1 (DM1). METHODS: Phenotypes were assessed with standardized measures. Pyrosequencing of bisulfite-treated...

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Vydáno v:Neurol Genet
Hlavní autoři: Légaré, Cécilia, Overend, Gayle, Guay, Simon-Pierre, Monckton, Darren G., Mathieu, Jean, Gagnon, Cynthia, Bouchard, Luigi
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568328/
https://ncbi.nlm.nih.gov/pubmed/31334355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXG.0000000000000338
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