Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Mammalian folate metabolism is comprised of cytosolic and mitochondrial pathways with nearly identical core reactions, yet the functional advantages of such an organization are not well understood. Using genome-editing and biochemical approaches, we find that ablating folate metabolism in the mitoch...

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Publicado en:Cell
Main Authors: Zheng, Yuxiang, Lin, Ting-Yu, Lee, Gina, Paddock, Marcia N., Momb, Jessica, Cheng, Zhe, Li, Qian, Fei, Dennis L., Stein, Benjamin D., Ramsamooj, Shivan, Zhang, Guoan, Blenis, John, Cantley, Lewis C.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568313/
https://ncbi.nlm.nih.gov/pubmed/30500537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.09.041
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