Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Mammalian folate metabolism is comprised of cytosolic and mitochondrial pathways with nearly identical core reactions, yet the functional advantages of such an organization are not well understood. Using genome-editing and biochemical approaches, we find that ablating folate metabolism in the mitoch...

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Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Zheng, Yuxiang, Lin, Ting-Yu, Lee, Gina, Paddock, Marcia N., Momb, Jessica, Cheng, Zhe, Li, Qian, Fei, Dennis L., Stein, Benjamin D., Ramsamooj, Shivan, Zhang, Guoan, Blenis, John, Cantley, Lewis C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568313/
https://ncbi.nlm.nih.gov/pubmed/30500537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.09.041
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