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B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors

BACKGROUND: PD-1 inhibitors are approved for multiple malignancies and function by stimulating T cells. However, the role of B cells in the anti-tumor activity of these drugs is unknown, as is their activity in patients who have received B cell depleting drugs or with immunoglobulin deficiencies. ME...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Damsky, William, Jilaveanu, Lucia, Turner, Noel, Perry, Curtis, Zito, Christopher, Tomayko, Mary, Leventhal, Jonathan, Herold, Kevan, Meffre, Eric, Bosenberg, Marcus, Kluger, Harriet M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567557/
https://ncbi.nlm.nih.gov/pubmed/31200747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0613-1
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