Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity

Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes in order to determine drug metabolism and evaluate the toxicity of xenobiotics. In this work, we established novel transgenic HepaRG...

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Publicado en:Sensors (Basel)
Autores principales: Vlach, Manuel, Quesnot, Nicolas, Dubois-Pot-Schneider, Hélène, Ribault, Catherine, Verres, Yann, Petitjean, Kilian, Rauch, Claudine, Morel, Fabrice, Robin, Marie-Anne, Corlu, Anne, Loyer, Pascal
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567340/
https://ncbi.nlm.nih.gov/pubmed/31096615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/s19102245
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