Hypoxia-Induced Epithelial-To-Mesenchymal Transition Mediates Fibroblast Abnormalities via EKR Activation in Cutaneous Wound Healing

Previous studies described the involvement of extracellular signal-related kinase (ERK) in systemic fibrotic diseases, but the role of ERK in cutaneous scarring is unknown. Although hypoxia drives tissue fibrosis by activating hypoxia-inducible factor-1α (HIF-1α), the specific roles of hypoxia and a...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Kim, Jihee, Kim, Bomi, Kim, Soo Min, Yang, Chae Eun, Song, Seung Yong, Lee, Won Jai, Lee, Ju Hee
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566997/
https://ncbi.nlm.nih.gov/pubmed/31137604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102546
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