Fibroblast-Specific Deletion of Hypoxia Inducible Factor-1 Critically Impairs Murine Cutaneous Neovascularization and Wound Healing

BACKGROUND: Diabetes and aging are known risk factors for impaired neovascularization in response to ischemic insult, resulting in chronic wounds, and poor outcomes following myocardial infarction and cerebrovascular injury. Hypoxia-inducible factor (HIF)-1α, has been identified as a critical regula...

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Veröffentlicht in:Plast Reconstr Surg
Hauptverfasser: Duscher, Dominik, Maan, Zeshaan N., Whittam, Alexander J., Sorkin, Michael, Hu, Michael S., Walmsley, Graham G., Baker, Hutton, Fischer, Lauren H., Januszyk, Michael, Wong, Victor W., Gurtner, Geoffrey C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951620/
https://ncbi.nlm.nih.gov/pubmed/26505703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PRS.0000000000001699
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