Francisella tularensis: FupA mutation contributes to fluoroquinolone resistance by increasing vesicle secretion and biofilm formation

Francisella tularensis is the causative agent in tularemia for which the high prevalence of treatment failure and relapse is a major concern. Directed-evolution experiments revealed that acquisition of fluoroquinolone (FQ) resistance was linked to factors in addition to mutations in DNA gyrase. Here...

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Udgivet i:Emerg Microbes Infect
Main Authors: Siebert, Claire, Lindgren, Helena, Ferré, Sabrina, Villers, Corinne, Boisset, Sandrine, Perard, Julien, Sjöstedt, Anders, Maurin, Max, Brochier-Armanet, Céline, Couté, Yohann, Renesto, Patricia
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566608/
https://ncbi.nlm.nih.gov/pubmed/31164053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2019.1615848
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