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Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida

Fluoroquinolone (FQ) resistance is a major health concern in the treatment of tularemia. Because DNA gyrase has been described as the main target of these compounds, our aim was to clarify the contributions of both GyrA and GyrB mutations found in Francisella novicida clones highly resistant to FQs....

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Caspar, Yvan, Siebert, Claire, Sutera, Vivien, Villers, Corinne, Aubry, Alexandra, Mayer, Claudine, Maurin, Max, Renesto, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5365679/
https://ncbi.nlm.nih.gov/pubmed/28167561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02277-16
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