Impact of CYP3A5, POR, and CYP2C19 Polymorphisms on Trough Concentration to Dose Ratio of Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplantation

Single nucleotide polymorphisms in drug-metabolizing genes may affect tacrolimus pharmacokinetics. Here, we investigated the influence of genotypes of CYP3A5, CYP2C19, and POR on the concentration/dose (C/D) ratio of tacrolimus and episodes of acute graft-versus-host disease (GVHD) in Japanese recip...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Suetsugu, Kimitaka, Mori, Yasuo, Yamamoto, Nanae, Shigematsu, Tomohiro, Miyamoto, Toshihiro, Egashira, Nobuaki, Akashi, Koichi, Masuda, Satohiro
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566597/
https://ncbi.nlm.nih.gov/pubmed/31096684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102413
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