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Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker

With the advent of personalized medicine, clinical trials studying treatment effects in subpopulations are receiving increasing attention. The objectives of such studies are, besides demonstrating a treatment effect in the overall population, to identify subpopulations, based on biomarkers, where th...

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Detalhes bibliográficos
Publicado no:Stat Methods Med Res
Main Authors: Graf, Alexandra Christine, Wassmer, Gernot, Friede, Tim, Gera, Roland Gerard, Posch, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566459/
https://ncbi.nlm.nih.gov/pubmed/29888651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280218777538
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