Universal Correction of Blood Coagulation Factor VIII in Patient-Derived Induced Pluripotent Stem Cells Using CRISPR/Cas9

Hemophilia A (HA) is caused by genetic mutations in the blood coagulation factor VIII (FVIII) gene. Genome-editing approaches can be used to target the mutated site itself in patient-derived induced pluripotent stem cells (iPSCs). However, these approaches can be hampered by difficulty in preparing...

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Publicat a:Stem Cell Reports
Autors principals: Park, Chul-Yong, Sung, Jin Jea, Cho, Sung-Rae, Kim, Jongwan, Kim, Dong-Wook
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2019
Matèries:
Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6565751/
https://ncbi.nlm.nih.gov/pubmed/31105049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.04.016
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