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The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo

Prion-like domains (PLDs), defined by their low sequence complexity and intrinsic disorder, are present in hundreds of human proteins. Although gain-of-function mutations in the PLDs of neuronal RNA-binding proteins have been linked to neurodegenerative disease progression, the physiological role of...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Vijayakumar, Jeshlee, Perrois, Charlène, Heim, Marjorie, Bousset, Luc, Alberti, Simon, Besse, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6565635/
https://ncbi.nlm.nih.gov/pubmed/31197139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10554-w
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