Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

Primary microcephaly is caused by mutations in genes encoding centrosomal proteins including WDR62 and KIF2A. However, mechanisms underlying human microcephaly remain elusive. By creating mutant mice and human cerebral organoids, here we found that WDR62 deletion resulted in a reduction in the size...

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Publicado no:Nat Commun
Main Authors: Zhang, Wei, Yang, Si-Lu, Yang, Mei, Herrlinger, Stephanie, Shao, Qiang, Collar, John L., Fierro, Edgar, Shi, Yanhong, Liu, Aimin, Lu, Hui, Herring, Bruce E., Guo, Ming-Lei, Buch, Shilpa, Zhao, Zhen, Xu, Jian, Lu, Zhipeng, Chen, Jian-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6565620/
https://ncbi.nlm.nih.gov/pubmed/31197141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10497-2
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