Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci

We evaluate whether human induced pluripotent stem cell-derived retinal pigment epithelium (iPSC-RPE) cells can be used to prioritize and functionally characterize causal variants at age-related macular degeneration (AMD) risk loci. We generated iPSC-RPE from six subjects and show that they have mor...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Smith, Erin N., D'Antonio-Chronowska, Agnieszka, Greenwald, William W., Borja, Victor, Aguiar, Lana R., Pogue, Robert, Matsui, Hiroko, Benaglio, Paola, Borooah, Shyamanga, D'Antonio, Matteo, Ayyagari, Radha, Frazer, Kelly A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6565613/
https://ncbi.nlm.nih.gov/pubmed/31080113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.04.012
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