L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation

L-N(G)-Nitro arginine methyl ester (L-NAME) has been widely applied for several decades in both basic and clinical research as an antagonist of nitric oxide synthase (NOS). Herein, we show that L-NAME slowly releases NO from its guanidino nitro group. Daily pretreatment of rats with L-NAME potentiat...

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Pubblicato in:Redox Biol
Autori principali: Liu, Taiming, Zhang, Meijuan, Mukosera, George T., Borchardt, Dan, Li, Qian, Tipple, Trent E., Ishtiaq Ahmed, Abu Shufian, Power, Gordon G., Blood, Arlin B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6565607/
https://ncbi.nlm.nih.gov/pubmed/31200239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101238
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