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Hemodynamic Effects of Glutathione-Liganded Binuclear Dinitrosyl Iron Complex: Evidence for Nitroxyl Generation and Modulation by Plasma Albumin

Glutathione-liganded binuclear dinitrosyl iron complex (glut-BDNIC) has been proposed to be a donor of nitric oxide (NO). This study was undertaken to investigate the mechanisms of vasoactivity, systemic hemodynamic effects, and pharmacokinetics of glut-BDNIC. To test the hypothesis that glut-BDNICs...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Pharmacol
Main Authors: Liu, Taiming, Zhang, Meijuan, Terry, Michael H., Schroeder, Hobe, Wilson, Sean M., Power, Gordon G., Li, Qian, Tipple, Trent E., Borchardt, Dan, Blood, Arlin B.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878675/
https://ncbi.nlm.nih.gov/pubmed/29476040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110957
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