Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease resulting from motor neuron degeneration that causes muscle weakness, paralysis, and eventually respiratory failure. We investigated whether recombinant adeno-associated virus encoding human hepatocyte growth factor (rAAV-HGF) coul...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Lee, Sang Hwan, Kim, Subin, Lee, Nayeon, Lee, Junghun, Yu, Seung Shin, Kim, Jin Hong, Kim, Sunyoung
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563368/
https://ncbi.nlm.nih.gov/pubmed/31189468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0737-z
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