Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia

BACKGROUND: Levodopa‐induced dyskinesias are an often debilitating side effect of levodopa therapy in Parkinson's disease. Although up to 90% of individuals with PD develop this side effect, uniformly effective and well‐tolerated antidyskinetic treatment remains a significant unmet need. The pa...

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Bibliografiske detaljer
Udgivet i:Mov Disord
Main Authors: Steece‐Collier, Kathy, Stancati, Jennifer A., Collier, Nicholas J., Sandoval, Ivette M., Mercado, Natosha M., Sortwell, Caryl E., Collier, Timothy J., Manfredsson, Fredric P.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563183/
https://ncbi.nlm.nih.gov/pubmed/31002755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27695
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