Radiosynthesis of (R,S)‐[(18)F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971

Translocator protein (TSPO) is a biomarker of neuroinflammation, which is a hallmark of many neurodegenerative diseases and has been exploited as a positron emission tomography (PET) target. Carbon‐11‐labelled PK11195 remains the most applied agent for imaging TSPO, despite its short‐lived isotope a...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Qiao, Luxi, Fisher, Emily, McMurray, Lindsay, Milicevic Sephton, Selena, Hird, Matthew, Kuzhuppilly‐Ramakrishnan, Nisha, Williamson, David J., Zhou, Xiouyun, Werry, Eryn, Kassiou, Michael, Luthra, Saijinder, Trigg, William, Aigbirhio, Franklin I.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563049/
https://ncbi.nlm.nih.gov/pubmed/30900397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900023
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