Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury

Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin induces iron sequestration to limit iron avai...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Scindia, Yogesh, Wlazlo, Ewa, Leeds, Joseph, Loi, Valentina, Ledesma, Jonathan, Cechova, Sylvia, Ghias, Elizabeth, Swaminathan, Sundararaman
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563000/
https://ncbi.nlm.nih.gov/pubmed/31244655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00615
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