Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury

Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin induces iron sequestration to limit iron avai...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Scindia, Yogesh, Wlazlo, Ewa, Leeds, Joseph, Loi, Valentina, Ledesma, Jonathan, Cechova, Sylvia, Ghias, Elizabeth, Swaminathan, Sundararaman
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563000/
https://ncbi.nlm.nih.gov/pubmed/31244655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00615
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