Patients carrying CYP2C8*3 have shorter systemic paclitaxel exposure

AIM: First, evaluate if patients carrying putatively diminished activity CYP2C8 genotype have longer paclitaxel exposure (e.g., time above threshold concentration of 0.05 μM [T(c >0.05)]). Second, screen additional pharmacogenes for associations with T(c >0.05). METHODS: Pharmacogene panel gen...

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Udgivet i:Pharmacogenomics
Main Authors: Marcath, Lauren A, Kidwell, Kelley M, Robinson, Adam C, Vangipuram, Kiran, Burness, Monika L, Griggs, Jennifer J, Poznak, Catherine Van, Schott, Anne F, Hayes, Daniel F, Henry, Norah Lynn, Hertz, Daniel L
Format: Artigo
Sprog:Inglês
Udgivet: Future Medicine Ltd 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562943/
https://ncbi.nlm.nih.gov/pubmed/30520341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs-2018-0162
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