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Loss of Prefrontal Cortical Higher Cognition with Uncontrollable Stress: Molecular Mechanisms, Changes with Age, and Relevance to Treatment

The newly evolved prefrontal cortex (PFC) generates goals for “top-down” control of behavior, thought, and emotion. However, these circuits are especially vulnerable to uncontrollable stress, with powerful, intracellular mechanisms that rapidly take the PFC “off-line.” High levels of norepinephrine...

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Bibliografski detalji
Izdano u:Brain Sci
Glavni autori: Datta, Dibyadeep, Arnsten, Amy F. T.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562841/
https://ncbi.nlm.nih.gov/pubmed/31108855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/brainsci9050113
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