A Comparison of DNA Mutation and Copy Number Profiles of Primary Breast Cancers and Paired Brain Metastases for Identifying Clinically Relevant Genetic Alterations in Brain Metastases

Improving the systemic treatment of brain metastases (BM) in primary breast cancer (PBC) is impaired by the lack of genomic characterization of BM. To estimate the concordance of DNA copy-number-alterations (CNAs), mutations, and actionable genetic alterations (AGAs) between paired samples, we perfo...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Tyran, Marguerite, Carbuccia, Nadine, Garnier, Séverine, Guille, Arnaud, Adelaïde, José, Finetti, Pascal, Touzlian, Julien, Viens, Patrice, Tallet, Agnès, Goncalves, Anthony, Metellus, Philippe, Birnbaum, Daniel, Chaffanet, Max, Bertucci, François
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562582/
https://ncbi.nlm.nih.gov/pubmed/31086113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050665
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