POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma

DNA Polymerase Theta (POLQ) is a DNA polymerase involved in error-prone translesion DNA synthesis (TLS) and error-prone repair of DNA double-strand breaks (DSBs). In the present study, we examined whether abnormal POLQ expression may be involved in the pathogenesis of lung adenocarcinoma (LAC). Firs...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Shinmura, Kazuya, Kato, Hisami, Kawanishi, Yuichi, Yoshimura, Katsuhiro, Tsuchiya, Kazuo, Takahara, Yoshiyuki, Hosokawa, Seiji, Kawase, Akikazu, Funai, Kazuhito, Sugimura, Haruhiko
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562496/
https://ncbi.nlm.nih.gov/pubmed/31137743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050722
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