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γ-Hydroxybutyric Acid (GHB) Pharmacokinetics and Pharmacodynamics: Semi-Mechanistic and Physiologically Relevant PK/PD Model

An overdose of γ-hydroxybutyric acid (GHB), a drug of abuse, results in fatality caused by severe respiratory depression. In this study, a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model was developed to characterize monocarboxylate transporter 1 (MCT1)-mediated transport of GHB, as w...

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Publicat a:AAPS J
Autors principals: Dave, Rutwij A., Follman, Kristin E., Morris, Marilyn E.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561755/
https://ncbi.nlm.nih.gov/pubmed/28653244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-017-0111-7
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