Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis

Mucorales are fungal pathogens that cause mucormycosis, a lethal angioinvasive disease. Previously, we demonstrated that Rhizopus, the most common cause of mucormycosis, invades endothelial cells by binding of its CotH proteins to the host receptor GRP78. Loss of CotH3 renders the fungus noninvasive...

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發表在:Sci Adv
Main Authors: Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Soliman, Sameh S. M., Gu, Yiyou, Jeon, Heewon H., Zhang, Lina, French, Samuel W., Stevens, David A., Edwards, John E., Filler, Scott G., Uppuluri, Priya, Ibrahim, Ashraf S.
格式: Artigo
語言:Inglês
出版: American Association for the Advancement of Science 2019
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561750/
https://ncbi.nlm.nih.gov/pubmed/31206021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw1327
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