Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis

Mucorales are fungal pathogens that cause mucormycosis, a lethal angioinvasive disease. Previously, we demonstrated that Rhizopus, the most common cause of mucormycosis, invades endothelial cells by binding of its CotH proteins to the host receptor GRP78. Loss of CotH3 renders the fungus noninvasive...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Soliman, Sameh S. M., Gu, Yiyou, Jeon, Heewon H., Zhang, Lina, French, Samuel W., Stevens, David A., Edwards, John E., Filler, Scott G., Uppuluri, Priya, Ibrahim, Ashraf S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561750/
https://ncbi.nlm.nih.gov/pubmed/31206021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw1327
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