Mitotane induces mitochondrial membrane depolarization and apoptosis in thyroid cancer cells

Mitotane is used for the treatment of adrenocortical cancer and elicits its anticancer effects via inhibition of mitochondrial respiration. Targeting mitochondria-dependent metabolism has emerged as a promising strategy for thyroid cancer (TC) treatment. We hypothesized that mitotane targets mitocho...

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Gepubliceerd in:Int J Oncol
Hoofdauteurs: Bikas, Athanasios, Jensen, Kirk, Patel, Aneeta, Costello, John, Kaltsas, Gregory, Hoperia, Victoria, Wartofsky, Leonard, Burman, Kenneth, Vasko, Vasyl
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: D.A. Spandidos 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561621/
https://ncbi.nlm.nih.gov/pubmed/31115496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2019.4802
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