Mitotane induces mitochondrial membrane depolarization and apoptosis in thyroid cancer cells

Mitotane is used for the treatment of adrenocortical cancer and elicits its anticancer effects via inhibition of mitochondrial respiration. Targeting mitochondria-dependent metabolism has emerged as a promising strategy for thyroid cancer (TC) treatment. We hypothesized that mitotane targets mitocho...

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Bibliografiske detaljer
Udgivet i:Int J Oncol
Main Authors: Bikas, Athanasios, Jensen, Kirk, Patel, Aneeta, Costello, John, Kaltsas, Gregory, Hoperia, Victoria, Wartofsky, Leonard, Burman, Kenneth, Vasko, Vasyl
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2019
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561621/
https://ncbi.nlm.nih.gov/pubmed/31115496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2019.4802
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