Mitotane induces mitochondrial membrane depolarization and apoptosis in thyroid cancer cells

Mitotane is used for the treatment of adrenocortical cancer and elicits its anticancer effects via inhibition of mitochondrial respiration. Targeting mitochondria-dependent metabolism has emerged as a promising strategy for thyroid cancer (TC) treatment. We hypothesized that mitotane targets mitocho...

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Bibliographic Details
Published in:Int J Oncol
Main Authors: Bikas, Athanasios, Jensen, Kirk, Patel, Aneeta, Costello, John, Kaltsas, Gregory, Hoperia, Victoria, Wartofsky, Leonard, Burman, Kenneth, Vasko, Vasyl
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561621/
https://ncbi.nlm.nih.gov/pubmed/31115496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2019.4802
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