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NURR1 activation in skeletal muscle controls systemic energy homeostasis

Skeletal muscle plays a central role in the control of metabolism and exercise tolerance. Analysis of muscle enhancers activated after exercise in mice revealed the orphan nuclear receptor NURR1/NR4A2 as a prominent component of exercise-responsive enhancers. We show that exercise enhances the expre...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Amoasii, Leonela, Sanchez-Ortiz, Efrain, Fujikawa, Teppei, Elmquist, Joel K., Bassel-Duby, Rhonda, Olson, Eric N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561277/
https://ncbi.nlm.nih.gov/pubmed/31110021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902490116
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