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A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor

As 3D culture has become central to investigation of tissue biology, mammary epithelial organoids have emerged as powerful tools for investigation of epithelial cell polarization and carcinogenesis. However, most current protocols start from single cells suspended in Matrigel, which can also restric...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Florian, Stefan, Iwamoto, Yoshiko, Coughlin, Margaret, Weissleder, Ralph, Mitchison, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561274/
https://ncbi.nlm.nih.gov/pubmed/31101720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702372116
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