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Crystal structures of Ca(2+)–calmodulin bound to Na(V) C-terminal regions suggest role for EF-hand domain in binding and inactivation
Voltage-gated sodium (Na(V)) and calcium channels (Ca(V)) form targets for calmodulin (CaM), which affects channel inactivation properties. A major interaction site for CaM resides in the C-terminal (CT) region, consisting of an IQ domain downstream of an EF-hand domain. We present a crystal structu...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561220/ https://ncbi.nlm.nih.gov/pubmed/31072926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818618116 |
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