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Inherent flexibility determines the transition mechanisms of the EF-hands of calmodulin

We explore how inherent flexibility of a protein molecule influences the mechanism controlling allosteric transitions by using a variational model inspired from work in protein folding. The striking differences in the predicted transition mechanism for the opening of the two domains of calmodulin (C...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Tripathi, Swarnendu, Portman, John J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2009
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650115/
https://ncbi.nlm.nih.gov/pubmed/19190183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806872106
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