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Inherent flexibility determines the transition mechanisms of the EF-hands of calmodulin
We explore how inherent flexibility of a protein molecule influences the mechanism controlling allosteric transitions by using a variational model inspired from work in protein folding. The striking differences in the predicted transition mechanism for the opening of the two domains of calmodulin (C...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650115/ https://ncbi.nlm.nih.gov/pubmed/19190183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806872106 |
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