Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides

Ribozymes synthesize proteins in a highly regulated local environment to minimize side reactions caused by various competing species. In contrast, it is challenging to prepare synthetic polypeptides from the polymerization of N-carboxyanhydrides (NCAs) in the presence of water and impurities, which...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Song, Ziyuan, Fu, Hailin, Wang, Jiang, Hui, Jingshu, Xue, Tianrui, Pacheco, Lazaro A., Yan, Haoyuan, Baumgartner, Ryan, Wang, Zhiyu, Xia, Yingchun, Wang, Xuefang, Yin, Lichen, Chen, Chongyi, Rodríguez-López, Joaquín, Ferguson, Andrew L., Lin, Yao, Cheng, Jianjun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561217/
https://ncbi.nlm.nih.gov/pubmed/31088971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901442116
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