Applying causal models to explore the mechanism of action of simvastatin in progressive multiple sclerosis

Understanding the mode of action of drugs is a challenge with conventional methods in clinical trials. Here, we aimed to explore whether simvastatin effects on brain atrophy and disability in secondary progressive multiple sclerosis (SPMS) are mediated by reducing cholesterol or are independent of c...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Eshaghi, Arman, Kievit, Rogier A., Prados, Ferran, Sudre, Carole H., Nicholas, Jennifer, Cardoso, M. Jorge, Chan, Dennis, Nicholas, Richard, Ourselin, Sebastien, Greenwood, John, Thompson, Alan J., Alexander, Daniel C., Barkhof, Frederik, Chataway, Jeremy, Ciccarelli, Olga
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561162/
https://ncbi.nlm.nih.gov/pubmed/31072935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818978116
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